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<!DOCTYPE html><html lang="en" style="background-color:#ffffff;margin:0;padding:0"><head> <title>Scholar Rock</title> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8"> <meta name="viewport" content="width=device-width"> <!--[if gte mso 9]><xml><o:OfficeDocumentSettings><o:AllowPNG/><o:PixelsPerInch>96</o:PixelsPerInch></o:OfficeDocumentSettings></xml> <![endif]--> <!--[if (gte mso 15)|(IE)]> <style type="text/css"> table{border-collapse:collapse;border-spacing:0;mso-line-height-rule:exactly;mso-margin-bottom-alt:0;mso-margin-top-alt:0;mso-table-lspace:0pt;mso-table-rspace:0pt;} </style> <![endif]--> <!--[if gte mso 9]> <style>li{margin-left:12px !important;mso-special-format:bullet;} </style> <![endif]--> <!--[if gte mso 9]> <style>sup,sub{font-size:100% !important;} </style> <![endif]--> <style>#outlook a{padding:0;}.ReadMsgBody{width:100%;}body,table,td,a{-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%;}table,td{mso-table-lspace:0pt;mso-table-rspace:0pt;}img{-ms-interpolation-mode:bicubic;}body{margin:0;padding:0;}img{border:0;height:auto;line-height:100%;outline:none;text-decoration:none;}table{border-collapse:collapse!important;border-spacing:0!important;}html,body{margin:0 auto!important;padding:0!important;height:100%!important;width:100%!important;}p{margin:0 !important;padding:0!important;}a{text-decoration:none;} </style> </head> <body width="100%" style="margin:0;color:#000000;font-family:Arial,Helvetica,Verdana,sans-serif;font-size:16px;line-height:22px;mso-line-height-rule:exactly;-webkit-font-smoothing:antialiased;-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;background-color:#ffffff;padding:0;height:100%;width:100%"><center style="width:100%"><div style="display:none;width:0;height:0;max-height:0;line-height:0;mso-hide:all;overflow:hidden;visibility:hidden;padding:0;margin:0;"> Important information to share ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ </div> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%" role="none"><tbody><tr><td align="center" bgcolor="#ececec" style="box-sizing:border-box;font-family:Verdana,sans-serif;vertical-align:top;" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;background-color:#ECECEC;" role="none"><tbody><tr><td align="center" style="padding-top:12px;padding-bottom:12px;padding-left:0;padding-right:0;box-sizing:border-box;"> <a href="https://scholarrock.com" target="_blank"><img src="https://emails.scholar-rock.cglife.dev/emails/outlook-email-BLA-announcement/images/outlook/corporate/logo-scholar-rock.png" width="140" height="60" border="0" alt="Scholar Rock" style="max-width:100%;vertical-align:middle;-ms-interpolation-mode:bicubic"></a> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%" role="none"><tbody><tr><td align="center" bgcolor="#ffffff" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;background-color:#ffffff;padding:20px;padding-bottom:40px;padding-top:48px"><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:16px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:20px;line-height:28px; font-weight:400;color:#000000"><p style="margin:0;margin-bottom:0;mso-line-height-rule:exactly;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:20px;line-height:28px;font-weight:700;color:#FF00FB"> <span style="color:#000000">Dear</span> [Dr/Doctor/Miss/Mr/Mrs/Ms/blank] [First Name/Last Name][, MD/, PharmD/, PA/, NP/, DO/blank]<span style="color:#000000">,</span></p></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:16px;mso-line-height-rule:exactly; text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:16px;line-height:22px;color:#000000"> I am happy to share with you that earlier this week Scholar Rock resubmitted our Biologics License Application for our spinal muscular atrophy (SMA) investigational treatment. </div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:16px;mso-line-height-rule:exactly;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:16px;line-height:22px;color:#000000"> We anticipate an FDA decision in 2026 and look forward to serving the SMA community. </div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:16px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:18px;line-height:28px;font-weight:400;color:#000000"><p style="margin:0;margin-bottom:0;mso-line-height-rule:exactly;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:18px;line-height:28px;color:#FF00FB"> [Please find additional details <a href="https://scholarrock.com/" target="_blank" style="color:#FF00FB;text-decoration:underline">here</a>./For additional details, please see our <a href="https://scholarrock.com/" target="_blank" style="color:#FF00FB;text-decoration:underline">press release</a>.] </p></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:16px;mso-line-height-rule:exactly;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:16px;line-height:22px;color:#000000"> Best, </div> <div style="box-sizing:border-box;display:block;margin:0;margin-bottom:4px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:18px;line-height:28px;font-weight:400;color:#000000"><p style="margin:0;margin-bottom:0;mso-line-height-rule:exactly;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:18px;line-height:28px;color:#FF00FB"> [Representative first name and last name] </p></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:4px;text-align: left;font-family:Arial,Helvetica,sans-serif;font-size:18px;line-height:28px;font-weight:400;color:#000000"><p style="margin:0;margin-bottom:0;mso-line-height-rule:exactly;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:18px;line-height:28px;color:#FF00FB"> [Representative title] </p></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:4px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:18px;line-height:28px;font-weight:400;color:#000000"> <p style="margin:0;margin-bottom:0;mso-line-height-rule:exactly;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:18px;line-height:28px;color:#FF00FB"> [Representative email address] </p></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:4px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:18px;line-height:28px;font-weight:400;color:#000000"><p style="margin:0;margin-bottom:0;mso-line-height-rule:exactly;text-align:left;font-family:Arial, Helvetica,sans-serif;font-size:18px;line-height:28px;color:#FF00FB"> [Representative phone number] </p></div> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%" role="none"><tbody><tr><td align="center" bgcolor="#196162" style="padding:0 0 20px 0;padding-bottom:20px;box-sizing:border-box;font-family:Verdana,sans-serif;vertical-align:top;" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;background-color:#196162;" role="none"><tbody><tr><td style="padding-top:52px;padding-left:20px;padding-right:20px;padding-bottom:60px;box-sizing:border-box;"> <table border="0" cellpadding="0" cellspacing="0" width="100%" role="none"><tbody><tr><td align="center" style="padding:0;"><div style="box-sizing:border-box;text-align:center;display:block;margin:0 auto;margin-bottom:8px;"> <a href="https://scholarrock.com" target="_blank"><img src="https://emails.scholar-rock.cglife.dev/emails/outlook-email-BLA-announcement/images/outlook/corporate/logo-footer-scholar-rock.png" width="140" height="60" border="0" alt="Scholar Rock" style="max-width:100%;vertical-align:middle;-ms-interpolation-mode:bicubic"></a></div><div style="box-sizing: border-box;text-align:center;display:block;margin:0;margin-bottom:12px;font-family:Arial,Helvetica,Verdana,sans-serif;color:#ffffff;font-size:12px;line-height:16px;font-weight:normal;"> 301 Binney St., 3rd Floor<br>Cambridge, MA 02142 </div><div style="box-sizing:border-box;text-align:center;display:block;margin:0;margin-bottom:12px;font-family:Arial,Helvetica,Verdana,sans-serif;color:#ffffff;font-size:12px;line-height:16px;font-weight:normal;"> <a href="https://scholarrock.com/our-company/" target="_blank" style="color:#ffffff;text-decoration:underline;">About Scholar Rock</a> | <a href="https://scholarrock.com/privacy-policy/" target="_blank" style="color:#ffffff;text-decoration:underline;">Privacy Policy</a> | <a href="https://scholarrock.com/terms-of-use/" target="_blank" style="color:#ffffff;text-decoration:underline;">Terms of Use</a> | <a href="https://scholarrock.com/contact-us/" target="_blank" style="color:#ffffff;text-decoration:underline;">Contact Us</a></div><div style="box-sizing:border-box;text-align:center;display:block;margin:0;margin-bottom:12px;font-family:Arial,Helvetica,Verdana,sans-serif;color:#ffffff;font-size:12px;line-height:16px;font-weight:normal;"> Scholar Rock © 2026. All rights reserved. </div><div style="box-sizing:border-box;text-align:center;display:block;margin:0;margin-bottom:0; font-family:Arial,Helvetica,Verdana,sans-serif;color:#ffffff;font-size:12px;line-height:16px;font-weight:normal;"> US-APIT-0393 04/26 </div> </td></tr></tbody></table> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table></center> </body></html>